C.J.'s Game follows Charles Jackson (C.J.), a man tormented by his past and struggling with mounting crises. After his trucking business is destroyed in a fire and his wife, Alicia, threatens to leave him, C.J. returns to his dangerous past in high-stakes dice games with his old acquaintance, Yayo. A robbery leaves C.J. beaten and betrayed, discovering Yayo may have set him up. As Alicia leaves him and his life unravels, C.J. teams up with Detective Rich Davis to confront Yayo, determined to settle the score and reclaim his life at any cost.